Posted: Thu May 20, 2010 6:22 pm
3rd time i try answering here! Yesterday and one day before i allways fallen asleep. Still fighting against tiredness 
Ty Wolf, thats interessting stuff!
This virus stuff is evolutionarly in child´s shoes same as transplantation of cord blood. But such stuff is definite the future.
How dangerous this new things can also be showed the antibody
TGN1412 .
There are 5 steps/phases to get a medic market ready (phase 0 to 4), and are allways made by clinical studies/trials. B4 to reach the first phase all the medics was testet about 10 years on animals or in vitro/in vivo (prehospital study).
Phase 0: 0 to 10 peeps (microdosing)
Phase 1: 10 to 20 peeps (tolerance and safeness of the medic - FIM "First in Man")
Phase 2: 20 to 200 peeps (validation/verification/checkup of results/effect). Divided into 2a (Proof of Concept), and 2b (Dose Finding)
Phase 3: 200 to 1000 - 10,000 peeps (3a pivotal study, after market authorization go into 3b studies)
Phase 4: above 1000 to 10,000 peeps (some admission boards command/demand such studies for verification of extremly rarely side effects, or to marketing purposes)
Ok, enough babbeld
Fact is that i have to make the bone marrow transplatation in fall (or earlier), and its my only chance to get healed. Whatever the docs mean with it (cause my definiton of the word "to be healed" can be different to the docs definition - state till now - have to make some important questions next visit).
This month is my last one of working. After the transplantation i can not resume this cause its too "dirty". I ll get a retraining to something/anything, but thats a other story.
A other fact is that after transplantation there is a timeframe, where a risk of relapse is existing. If i have a relapse then the story come to a fast end, cause a second transplantation is impossible. If that happens they can only the life extend for unknown time.
This timeframe is about 2 years. After 2 years the relapse danger should be banned.
Here is a stream that is very important 4 me! She got the bone marrow like me from the brother, and after 1 and a half year diagnosis: relapse.
They wanted to made a vid about her recovery, but it came the other way - the movie changed to attendance? till to the end.
I am sorry, its non english and i found not a subtitle version, and it take one hour to watch it.
Best i like is part 6/6, where the friends of Suasanne telling what life is (loosing in daily rutine things 1:10 , or what is rly important in life 2:10), and that last part shows also at the end that life goes on.
Marwin
Edith: Forgot the link:
Here the first one of 6.
[youtube]http://www.youtube.com/watch?v=wwnpJVzIyF0[/youtube]
Ty Wolf, thats interessting stuff!
This virus stuff is evolutionarly in child´s shoes same as transplantation of cord blood. But such stuff is definite the future.
How dangerous this new things can also be showed the antibody
TGN1412 .
There are 5 steps/phases to get a medic market ready (phase 0 to 4), and are allways made by clinical studies/trials. B4 to reach the first phase all the medics was testet about 10 years on animals or in vitro/in vivo (prehospital study).
Phase 0: 0 to 10 peeps (microdosing)
Phase 1: 10 to 20 peeps (tolerance and safeness of the medic - FIM "First in Man")
Phase 2: 20 to 200 peeps (validation/verification/checkup of results/effect). Divided into 2a (Proof of Concept), and 2b (Dose Finding)
Phase 3: 200 to 1000 - 10,000 peeps (3a pivotal study, after market authorization go into 3b studies)
Phase 4: above 1000 to 10,000 peeps (some admission boards command/demand such studies for verification of extremly rarely side effects, or to marketing purposes)
Ok, enough babbeld
Fact is that i have to make the bone marrow transplatation in fall (or earlier), and its my only chance to get healed. Whatever the docs mean with it (cause my definiton of the word "to be healed" can be different to the docs definition - state till now - have to make some important questions next visit).
This month is my last one of working. After the transplantation i can not resume this cause its too "dirty". I ll get a retraining to something/anything, but thats a other story.
A other fact is that after transplantation there is a timeframe, where a risk of relapse is existing. If i have a relapse then the story come to a fast end, cause a second transplantation is impossible. If that happens they can only the life extend for unknown time.
This timeframe is about 2 years. After 2 years the relapse danger should be banned.
Here is a stream that is very important 4 me! She got the bone marrow like me from the brother, and after 1 and a half year diagnosis: relapse.
They wanted to made a vid about her recovery, but it came the other way - the movie changed to attendance? till to the end.
I am sorry, its non english and i found not a subtitle version, and it take one hour to watch it.
Best i like is part 6/6, where the friends of Suasanne telling what life is (loosing in daily rutine things 1:10 , or what is rly important in life 2:10), and that last part shows also at the end that life goes on.
Marwin
Edith: Forgot the link:
Here the first one of 6.
[youtube]http://www.youtube.com/watch?v=wwnpJVzIyF0[/youtube]
